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Cocoa's Brain Anti-Aging Benefits Affirmed
Clinical trial finds brain and cardio-metabolic benefits; vascular effects may be common factor

05/26/2015 By Craig Weatherby
Can the antioxidants in cocoa aid cognition?
 
A growing body of evidence suggests that these rare compounds really can.
 
And the results of a new clinical trial in older people adds more support for the idea.
 
It’s common for brain functions to deteriorate with age, with the speed and extent of that decline depending on genetics, diet, and activity levels. 
 
Delaying the onset of mental decline is a personal and societal concern, as life expectancy gets longer and populations age worldwide.
 
As we age, memory capacity begins to worsen, along with thinking speed, "executive” brain functions, and the ability to form long-term memories.
 
We’ve reported some of the earlier studies on cocoa and cognition; see these and related articles in the Cocoa, Tea & Coffee section of our news archive:
Now, another trial supports the potential value of antioxidant-rich cocoa for preserving mental powers as we age.
 
New trial finds brain and vascular benefits in healthy seniors
The new trial was conducted by researchers from Italy’s University of L’Aquila and candy maker Mars, Inc. (Mastroiacovo D et al. 2015) 
 
This was the second installment in a two-part investigation by the same team.
 
The first study found that high-flavanol cocoa produced cognitive and cardio-metabolic benefits in older adults who’d been diagnosed with mild cognitive impairment or MCI ... see Cocoa Bolstered Seniors' Brains.
 
But it remained uncertain whether the benefits of cocoa flavanols would apply to people without MCI … so this second study was designed to address that question.
 
The team enrolled 90 men and women aged 61-85 years with no evidence of cognitive dysfunction, for a controlled, randomized, double-blind study.
 
The volunteers were placed in one of three groups, with each group assigned to consume a drink containing a different amount of cocoa flavanols (antioxidants) every day for eight weeks:
  • High-flavanol cocoa - 993 mg/serving
  • Medium-flavanol cocoa - 520 mg/serving
  • Low-flavanol cocoa - 48 mg/serving
After eight weeks, the people in high-flavanol cocoa group showed significantly improved cognitive function scores, as well as improved insulin-resistance and blood pressure scores.
 
The high- and intermediate-flavanol cocoa drinks were produced using Mars’ patented Cocoapro® process (which protects flavanols from destruction), while the low-flavanol drink was made with a normal, highly processed, alkalized ("Dutched") cocoa powder.
 
(Note: Vital Choice Organic 80% Extra Dark Chocolate is made with non-Dutched cocoa, and tests very high in flavanols ... see our our Antioxidants in Cocoa & Chocolate chart.)
 
Other than downing their assigned cocoa drink daily, the participants maintained their normal diets and lifestyles throughout the study.
 
At the start of the study and again after eight weeks, their cognitive function was assessed using a battery of tests that examined memory, retention, recall, and executive function.
 
Encouragingly, those in the high- and medium-flavanol drinks showed significant improvements in overall cognitive function after eight weeks.
 
The results suggest that even cognitively healthy people can rapidly benefit from regular consumption of cocoa flavanols.
 
In addition to evaluating cognitive function, the researchers also monitored insulin resistance, blood pressure, and other markers of cardio-metabolic health. 
 
As with cognitive functions, there was also evidence of improvements in these cardio-metabolic outcomes. 
 
Both systolic and diastolic blood pressures were reduced and insulin resistance was significantly improved in the high- and medium-flavanol groups.
 
In contrast, only a modest improvement in diastolic blood pressure was observed in the low-flavanol group, with no significant improvements in either systolic blood pressure or insulin resistance.
 
Scientists haven’t yet determined how cocoa flavanols improve cognitive function, but the study’s authors suggest that the improvements in insulin resistance and blood pressure could be partially responsible.
 
As lead author Giovambattista Desideri, M.D., said, "Earlier studies suggest a central role for insulin resistance in brain aging. These results could therefore provide some insight into a possible mechanism of action for the cognitive improvements we have observed.”
 
There has been significant evidence over the past decade that cocoa flavanols also improve vascular function.
 
Co-author Dr. Catherine Kwik-Uribe of Mars, Inc. pointed out the obvious: "Since the brain is a heavily vascularized tissue, we might also be looking at vascular improvements as underlying the observed improvements in cognitive function.”
 
Dr. Desideri and his team are planning their next steps: "Now we’d like to know how they [cocoa flavanols] work and how long the effects last. If these further studies confirm the findings … it may have the potential to affect the daily lives of millions of people worldwide.”
 
Although the study was funded by a chocolate maker, the co-authors were academic scientists and its findings fit with those of many other studies, so it should be taken seriously.
 
 
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