Study linked 6 types of exercise to reduced gene-driven risk for obesity 08/12/2019
Much of the world is getting fatter, thanks to the spread of American-style diets and sedentary lifestyles.
Weight gain is tough to combat — and weight loss is even harder — because it’s not just a function of what we eat, or our activity levels.
Instead, in addition to their diet and lifestyle, each person’s tendency to gain weight and their ability to lose excess weight is affected by their genetic profile.
Those weight-related tendencies and abilities are also affected by the mix of microbes in your gut: see Exercise Your Right to a Healthy Gut and its links to related articles.
Even though exercise is important for weight control, we’ve lacked conclusive evidence on the best types for suppressing the activity of genes that promote weight gain and boosting the activity of genes that help control weight.
Now, a study from Taiwan has taken a pretty big, albeit preliminary, step toward clarifying the answers to key questions about exercise, genes, and weight control.
Taiwanese study links six exercise types to beneficial gene effects
The new study comes from the National Taiwan University in Taipei and involved 18,424 Taiwanese adults aged 30 to 70 years.
The participants had previously supplied their health and lifestyle data, including blood samples, to the Taiwan Biobank, which is one of 16 national biobanks currently established around the world.
It’s clear that frequent physical activity blunts the effects of certain unhelpful gene variants — such as a variant of the FTO gene, which promotes a larger body mass index (BMI) and the risk of obesity among all ethnic groups studied to date.
But prior studies focused on the effects of exercise on FTO gene variants and other gene variants on body mass index (BMI) in particular.
As the authors of the new study wrote, “Previous studies have found that performing regular physical exercise could blunt the genetic effects on BMI [body mass index]. However, few studies have investigated BFP [body fat percentage] or measures of central obesity … [which] are even more relevant to health than BMI.”
In addition to BMI, the new Taiwanese study covered the effects of exercise on genes affecting four other measures of “central” obesity — such as body fat percentage — that are linked more closely to metabolic problems like obesity, diabetes, chronic inflammation, and unhealthful blood fat profiles.
Each individual participant’s genome was sequenced, which revealed key details about their distinct genetic profiles (Lin WY et al. 2019).
(Genome sequencing is the process of determining the order of the more than three billion DNA nucleotide molecules or “letters” — adenine (A), guanine (G), thymine (T), and cytosine (C) — in a person’s DNA.)
The scientists then calculated a genetic risk score (GRS) for each participant, based on data from prior studies that revealed links between specific gene variations, tendencies toward weight gain, and key aspects of body composition.
The researchers — led by two female professors, Wan-Yu Lin and Po-Hsiu Kuo — asked participants about their exercise routines.
Then, to calculate the effects of various types of exercise on gene-related risks for obesity, the scientists compared the participants’ answers about their exercise routine to their genetic profile and five aspects of body composition:
- Hip circumference
- Body fat percentage
- Waist circumference
- Body mass index (BMI)
- Waist-to-hip ratio (WHR)
The results of those calculations indicated that jogging is the best type of exercise for managing all five measures of body composition, and for overall efficacy at preventing obesity.
(Oddly, running was not included in the survey asking participants about their exercise habits. That omission may just be a matter of semantics: in Taiwan, the term “jogging” may be synonymous with running. It certainly seems safe to presume that running — which is typically faster and more vigorous than jogging — could be preferable for beneficially affecting weight-related genes.)
The runners-up (pardon the pun) were mountain climbing, walking, power walking, certain vigorous types of dancing, and longer yoga routines (one hour or more daily), which also reduced BMI among participants who were genetically predisposed to obesity.
Surprisingly, neither cycling, swimming, tai chi (and other forms of qigong), nor Dance Dance Revolution (DDR) appeared to counteract the effects of people’s genes on their tendency toward obesity.
(Dance Dance Revolution is an exercise/coordination game popular in East Asia, in which players step on colored arrows in response to increasingly rapid musical and visual cues. The inefficacy of DDR seen in this study may be related to the average frequency at which people engage in it, which may be low compared with other exercise routines.)
Less surprisingly, the researchers found that stretching exercises exerted no beneficial effects on obesity genes, probably because stretching does relatively little to raise a person’s metabolic rate.
Compared with yoga (379 practitioners), cycling (989 practitioners), stretching (602 practitioners), swimming (486 practitioners), DDR (420 practitioners), and qigong (377 practitioners) were more or just as popular — but evidence that these exerted beneficial effects on relevant genes was fairly weak.
The authors noted that few studies have investigated the interplay between specific types of exercise and genetic risk of obesity measures, making it difficult to compare their findings with those of other studies.
However, they proposed that jogging — compared, for example, to swimming and cycling — does more to raise metabolic rates and burn calories.
They also noted that swimming typically takes place in water cold enough to stimulate appetite and food intake. That may make swimming less effective than other exercises, in terms of desirable effects on obesity-related genes and weight control in general.
The study’s limitations and strengths
While of real value, this study’s findings can’t be considered definitive, for several reasons.
First, almost all the participants belonged to the Han Chinese ethnic group, whose genetic profile differs from other ethnic groups in ways that probably aren’t but could be significant.
For example, prior studies found that the genetic variations covered in this study promote weight gain in Han Chinese significantly less than in people of European descent — and that slightly fewer genetic variants affect weight control in Han Chinese versus Europeans (Zhu J et al. 2014).
Second, people’s reports of their regular exercise routines and levels of intensity are necessarily subjective, hence not fully reliable. (People responding to study surveys tend to overreport their exercise levels and underreport their caloric intakes.)
Finally, the numbers of people reporting that they routinely engage in certain activities — such as basketball and tennis — were too small to allow statistically meaningful analysis of their effects on weight-related genes.
And it seems likely that — compared with average Taiwanese people — fewer Americans engage in Dance Dance Revolution or in what most Americans would consider “mountain climbing”.
In Taiwan, the term “mountain climbing” is virtually synonymous with hiking, because mountains cover 70% of Taiwan’s land area. In fact, hiking up hills and mountains is a common activity in Taiwan, where many people try to climb all 100 of its tallest, most iconic peaks.
Nonetheless, the results of the new study add valuable evidence to an area of weight-control science that’s just getting underway.
Overall, the Taiwanese study suggests that when it comes to obesity, genes are not destiny, and that the undesirable effects of certain genes on weight can be eased by the right kinds of regular exercise.
- Deurenberg P, Deurenberg-Yap M, Guricci S (2002) Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev 3: 141–146.
- Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889–894.
- Jääskeläinen T, Paananen J, Lindström J, Eriksson JG, Tuomilehto J, Uusitupa M; Finnish Diabetes Prevention Study Group. Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study. Br J Nutr. 2013 Nov;110(10):1856-65. doi: 10.1017/S0007114513001116. Epub 2013 May 14.
- Lin WY, Chan CC, Liu YL, Yang AC, Tsai SJ, Kuo PH. Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants. PLoS Genet. 2019 Aug 1;15(8):e1008277. doi: 10.1371/journal.pgen.1008277. eCollection 2019 Aug.
- Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197–206. 10.1038/nature14177
- Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768–775.
- Ng MC, Tam CH, So WY, Ho JS, Chan AW, et al. (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95: 2418–2425.
- Okada Y, Kubo M, Ohmiya H, Takahashi A, Kumasaka N, et al. (2012) Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet 44: 302–306.
- Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937–948.
- Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18–24.
- Vimaleswaran KS, Li S, Zhao JH, Luan J, Bingham SA, Khaw KT, Ekelund U, Wareham NJ, Loos RJ. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr. 2009 Aug;90(2):425-8. doi: 10.3945/ajcn.2009.27652. Epub 2009 Jun 24.
- Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, et al. (2012) Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 44: 307–311.
- Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25–34.
- Zhu J, Loos RJ, Lu L, Zong G, Gan W, Ye X, Sun L, Li H, Lin X. Associations of genetic risk score with obesity and related traits and the modifying effect of physical activity in a Chinese Han population. PLoS One. 2014 Mar 13;9(3):e91442. doi: 10.1371/journal.pone.0091442. eCollection 2014