Eco-expert urges trials able to prove what she and her peers suspect 08/26/2019
This article was written by Assistant Professor Cynthia Curl, Ph.D., of Idaho’s Boise State University, and is republished from The Conversation under a Creative Commons license.
Dr. Curl is a pesticide expert who’s been featured in reports by The New York Times and NBC News. In 2018, she was named one of 20 pioneers in environmental public health under 40 by the Collaborative on Health and the Environment.
NOTE: You’ll find links to related articles from our newsletter archive within and at the end of this article.
Organic food benefits have been hard to assess, but that could change
by Cynthia Curl, Ph.D.
“Organic” is more than just a passing fad. Organic food sales totaled a record $45.2 billion in 2017, making it one of the fastest-growing segments of American agriculture.
While a small number of studies have shown associations between organic food consumption and decreased incidence of disease, no studies to date have been designed to answer the question of whether organic food consumption causes an improvement in health.
I’m an environmental health scientist who has spent over 20 years studying pesticide exposures in human populations.
Last month, my research group published a small study — see "Our pilot clinical trial points the way forward", below — that I believe suggests a path forward to answering the question of whether eating organic food actually improves health (Curl CL et al. 2019).
What we don’t know
According to the USDA, the organic label does not imply anything about health.
In 2015, Miles McEvoy, then chief of the National Organic Program for USDA, refused to speculate about any health benefits of organic food, saying the question wasn’t “relevant” to the National Organic Program.
Instead, the USDA’s definition of organic is intended to indicate production methods that “foster cycling of resources, promote ecological balance, and conserve biodiversity.”
While some organic consumers may base their purchasing decisions on factors like resource cycling and biodiversity, most report choosing organic because they think it’s healthier.
Sixteen years ago, I was part of the first study to look at the potential for an organic diet to reduce pesticide exposure. It focused on a group of synthetic pesticides called organophosphates, which have consistently been associated with negative effects on children’s brain development.
And we found that children who ate conventional diets had nine times higher exposure to these pesticides than children who ate organic diets. (Curl CL et al. 2003)
But while our results were novel, they didn’t answer the big question. As I told The New York Times in 2003, “People want to know, 'what does this really mean in terms of the safety of my kid'? But we don’t know. Nobody does.” Maybe not my most elegant quote, but it was true then, and it’s still true now.
Studies only hint at potential health benefits
Since 2003, several researchers have looked at whether a short-term switch from a conventional to an organic diet affects pesticide exposure.
These studies have lasted one to two weeks and have repeatedly shown that “going organic” can quickly lead to dramatic reductions in exposure to several different classes of pesticides.
Still, scientists can’t directly translate these lower exposures to meaningful conclusions about health. The dose makes the poison, and organic diet intervention studies to date have not looked at health outcomes.
The same is true for the other purported benefits of organic food. Organic milk has higher levels of healthy omega fatty acids and organic crops have higher antioxidant activity than conventional crops.
But are these differences substantial enough to meaningfully impact health? We don’t know. Nobody does.
Epidemiological studies need confirmation by clinical trials
Some epidemiologic research has been directed at this question. Epidemiology is the study of the causes of health and disease in human populations, as opposed to in specific people.
Most epidemiologic studies look at a group of people with a certain characteristic or behavior, and compare their health to that of a group without it. In the case of organic food, that means comparing the health of people who choose to eat organic to those who do not.
Several observational studies have shown that people who eat organic food are healthier than those who eat conventional diets. A recent French study followed 70,000 adults for five years and found that those who frequently ate organic developed 25% fewer cancers than those who never ate organic.
[Editor’s note: We covered that French study in Organic Foods Linked to Lower Cancer Risks.]
Other observational studies have shown organic food consumption to be associated with lower risk of diabetes, metabolic syndrome, pre-eclampsia and genital birth defects.
The problem with drawing firm conclusions from observational studies is something epidemiologists call “uncontrolled confounding.” This is the idea that there may be differences between groups that researchers cannot account for. In this case, people who eat organic food are more highly educated, less likely to be overweight or obese, and eat overall healthier diets than conventional consumers.
While good observational studies take into account things like education and diet quality, there remains the possibility that some other uncaptured difference between the two groups — beyond the decision to consume organic food — may be responsible for any health differences observed.
When researchers want to figure out whether a drug works, they don’t do observational studies. They conduct randomized clinical trials, where they randomly assign some people to take the drug and others to receive placebos or standard care. By randomly assigning people to groups, there’s less potential for uncontrolled confounding.
Our pilot clinical trial points the way forward
My research group’s recently published study shows how we could feasibly use randomized trial methods to investigate the potential for organic food consumption to affect health (Curl CL et al. 2019).
We recruited a small group of pregnant women during their first trimesters and randomly assigned them to receive weekly deliveries of either organic or conventional produce throughout their second and third trimesters. We then collected a series of urine samples to assess pesticide exposure.
And we found that those women who received organic produce had significantly lower exposure to certain pesticides (specifically, pyrethroid insecticides) than those who received conventional produce.
[Editor's note: Under current USDA Organic regulations, natural pyrethrin-type insecticides from chrysanthemums are allowed for use on organic farms. Pyrethrins are the most common ingredients in household insecticides. And pyrethrins have been gradually replacing synthetic organophosphate and organochloride pesticides — which are substantially more persistent and toxic to humans — on commercial farms. Pyrethroids are man-made counterparts not allowed for use on organic farms. Because they contain more toxic chrysanthemum compounds (six versus just one in pyrethroids), natural pyrethrins can be more effective against insect pests but more toxic to people and other mammals.]
On the surface, this seems like old news, but this study was different in three important ways:
- First, to our knowledge, it was the longest organic diet intervention to date — by far.
- It was also the first to occur in pregnant women. Fetal development is potentially the most sensitive period for exposures to neurotoxic agents like pesticides.
- Finally, in previous organic diet intervention studies, researchers typically changed participants’ entire diets — swapping a fully conventional diet for a fully organic one. In our study, we asked participants to supplement their existing diets with either organic or conventional produce. This is more consistent with the actual dietary habits of most people who eat organic food — occasionally, but not always.
Even with just a partial dietary change, we observed a significant difference in pesticide exposure between the two groups. We believe that this study shows that a long-term organic diet intervention can be executed in a way that is effective, realistic and feasible.
The next step is to do this same study but in a larger population. We would then want to assess whether there were any resulting differences in the health of the children as they grew older, by measuring neurological outcomes like IQ, memory and incidence of attention-deficit disorders.
By randomly assigning women to the organic and conventional groups, we could be sure any differences observed in their children’s health really were due to diet, rather than other factors common among people who consume organic food.
The public is sufficiently interested in this question, the organic market is large enough, and the observational studies suggestive enough to justify such a study.
Right now, we don’t know if an organic diet improves health, but based on our recent research, I believe we can find out.
You will find the original article at The Conversation.
In addition to the three Vital Choices articles linked to above, we recommend these prior reports from our news archive:
- Organic Crops' Nutrition Advantage
- Is Organic Food Really More Nutritious?
- Organic Crops Win for Antioxidants ... Again
- Organic Food Gets a (Bogus) Mixed Review
- Organic Produce and Milk Offer More Antioxidants and Omega-3s
- Strawberries Curb Cancer Cell Growth; Organic Berries Called Best
Studies that Dr. Curl co-authored and referenced in this article:
- Curl CL, Fenske RA, Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect. 2003 Mar;111(3):377-82.
- Curl CL, Porter J, Penwell I, Phinney R, Ospina M, Calafat AM. Effect of a 24-week randomized trial of an organic produce intervention on pyrethroid and organophosphate pesticide exposure among pregnant women. Environ Int. 2019 Jun 28:104957. doi: 10.1016/j.envint.2019.104957. [Epub ahead of print]