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Food, Health, and Eco-news
Omega-3s May Oppose Child Obesity
Poor maternal nutrition appears to change a child’s health outcomes, including weight 05/09/2011 By Craig Weatherby
Do maternal and infant diets affect people's health throughout life?
Although it may seem somehow unfair, a growing body of evidence suggests the answer is “yes”.
Surprisingly, connections between infant diets and adult disease were not closely examined until the 1990s, when a series of papers by Britain's David Barker, M.D., Ph.D., started the ball rolling.
Further research has led to increasingly wide acceptance of the “Barker Theory”, which holds that poor – or unbalanced – maternal nutrition leads to later heart disease, diabetes, breast and ovary cancers, osteoporosis, and other disorders.
Poor maternal nutrition appears to change the child's “phenotype” … a term that refers to physiological attributes that arise from the interactions between a person's genes and their lifestyle, including their diet in the womb and during infancy.
For example, a Swedish study published two years ago showed that children born to mothers who ate vegetables only three to five times per week were 71 percent more likely to develop type 1 diabetes, compared to children of women who ate vegetables daily during pregnancy (Brekke HK et al. 2010).
Now, the findings from a novel Harvard clinical study adds to growing evidence that maternal nutrition can influence a child's health prospects.
Low maternal omega-3 intake linked to babies' obesity risk
Adequate intake of omega-3 fatty acids during pregnancy may lower the risk of childhood obesity by almost one-third, according to new research from Harvard Medical School (Donahue SM et al. 2011).
Conversely, maternal diets high in omega-6 fatty acids (from vegetable oils) and low in omega-3s (from fish or fish oil) appeared to increase a child's risk for obesity.
Harvard researchers led by Emily Oken, M.D., determined children's risk of obesity by measuring their body mass index (BMI) and taking skinfold measurements at the scapula and triceps.
The study authors also estimated the mothers' omega-3 intake – based on the women's self-reported weekly fish intake – and measured the levels of omega-6 and omega-3 fatty acids in the babies' cord blood at delivery.
(Omega-3s and omega-6s compete for absorption into cell membranes, and diets high in omega-6s can limit the proportion of omega-3s.)
The Harvard team concluded that higher maternal omega-3 intake and higher omega-3 blood levels in newborns reduced the risk of childhood obesity.
The Harvard group then calculated the odds for obesity in the women's offspring at age three, and looked for links to the mother's omega-3 fatty acid intake and/or the level of omega-6 and omega-3 fats in cord blood at delivery.
Oken and her co-workers reported the odds of obesity in three-year-olds were between two and four times higher when cord blood had a high ratio of omega-6 to omega-3 fatty acids.
In contrast, the odds of obesity were 32 percent lower when maternal consumption of omega-3s was high or if the ratio of omega-3 to omega-6 intake was at or close to the recommended 1:3 ratio.
In other words, mothers who get too few omega-3 and too many omega-6 fats during pregnancy might raise their baby's odds of becoming obese.
As they wrote, “A higher ratio of cord plasma omega-6 to omega-3 polyunsaturated fatty acids was associated with higher sub-scapular and triceps [skinfold thicknesses] and odds of obesity,” they said.
Mothers' omega-3 intake generally inadequate
Dr. Oken and her colleagues reported that, at mid-pregnancy, only about one-fifth of the expectant mothers in their study reported eating more than the widely recommended two fish meals per week.
And only about half of these relatively frequent fish-eaters were estimated to achieve the widely recommended intake of DHA of at least 200mg per day … because they reported eating mostly lean white fish.
Worse, a mere three percent of the women in the study were estimated to get the recommended 200mg of omega-3 DHA per day during their last month of pregnancy.
As Oken's team noted, the last month of pregnancy is when large amounts of omega-3 DHA are transferred from mother to baby to support brain development.
Judging by their study participants' behavior, the authors hypothesized that even pregnant women who meet the two-meals-per-week intake guideline don't consume enough fatty, omega-3-rich fish … such as salmon, tuna, sardines, and mackerel.
Omega-3s and obesity risk: An overview
The Harvard team's report included an important caveat:
“These findings need to be confirmed by others. It will also be important to demonstrate that making deliberate changes to a woman's fat intake during pregnancy has desirable effects on weight and fatness in children.” (Donahue SM et al. 2011)
Two years ago, a team at Germany's Technical University Munich reported that they were undertaking just such a study … so we'll keep an eye out for their findings (Hauner H et al. 2009).
Although imbalances in fatty acid intake – too few omega-3s and too many omega-6s – promote the development of adipose (fatty) tissue in animals, very few clinical studies have tested this in people.
Indeed, when Norwegian researchers gave pregnant mothers either omega-3-rich cod liver oil or omega-6-rich corn oil from mid-pregnancy until three months after delivery, they found no link between the infants' omega-3 or omega-6 blood levels through the first three months of life and their BMI at age seven (Helland IB et al. 2008).
But body mass index is not a very accurate indicator of excess body fat, since people with more muscle mass than average have a high BMI without being overweight or obese.
Nor is the skinfold method used in the Harvard study perfect, because it estimates body density, not body fat percentage, which must be estimated by applying a mathematical formula … an approach with its own room for error.
However, as the American Heart Association says, “… children and adolescents assessed to have a skinfold measure greater than the 95th percentile are more likely to have excess body fat as opposed to increased lean body mass or large frame size.” (AHA 2011)
The Centers for Disease Control and Prevention defines overweight in children as having an age-adjusted BMI at or above the 95th percentile … and CDC recommends use of the triceps skinfold test for further evaluation when a child's BMI exceeds this level.
Finally, we should note that when it comes to the proposed capacity of omega-3s to help adults control their weight, the clinical evidence is mostly positive, but much too limited and mixed to be conclusive … see the “Omega-3s & Weight/Fitness” section of our news archive.
  • American Heart Association (AHA). Overweight in Children. Updated March 29, 2011. Accessed at
  • Bermúdez Menéndez de la Granda M, Sinclair AJ. Fatty acids and obesity. Curr Pharm Des. 2009;15(36):4117-25.
  • Brekke HK, Ludvigsson J. Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring--the ABIS study. Pediatr Diabetes. 2010 Jun;11(4):244-50. Epub 2009 Sep 16.
  • DeFina LF, Marcoux LG, Devers SM, Cleaver JP, Willis BL. Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. Am J Clin Nutr. 2011 Feb;93(2):455-62. Epub 2010 Dec 15.
  • Donahue SM, Rifas-Shiman SL, Gold DR, Jouni ZE, Gillman MW, Oken E. Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort. Am J Clin Nutr. 2011 Apr;93(4):780-8. Epub 2011 Feb 10.
  • Drouillet P, Forhan A, De Lauzon-Guillain B, Thiébaugeorges O, Goua V, Magnin G, Schweitzer M, Kaminski M, Ducimetière P, Charles MA. Maternal fatty acid intake and fetal growth: evidence for an association in overweight women. The 'EDEN mother-child' cohort (study of pre- and early postnatal determinants of the child's development and health). Br J Nutr. 2009 Feb;101(4):583-91. Epub 2008 Jul 17.
  • Hauner H, Vollhardt C, Schneider KT, Zimmermann A, Schuster T, Amann-Gassner U. The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study. Ann Nutr Metab. 2009;54(2):97-103. Epub 2009 Mar 19.
  • Helland IB, Smith L, Blomén B, Saarem K, Saugstad OD, Drevon CA. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics. 2008 Aug;122(2):e472-9.
  • Huber J, Löffler M, Bilban M, Reimers M, Kadl A, Todoric J, Zeyda M, Geyeregger R, Schreiner M, Weichhart T, Leitinger N, Waldhäusl W, Stulnig TM. Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids. Int J Obes (Lond). 2007 Jun;31(6):1004-13. Epub 2006 Nov 28.
  • Kunesová M, Braunerová R, Hlavatý P, Tvrzická E, Stanková B, Skrha J, Hilgertová J, Hill M, Kopecký J, Wagenknecht M, Hainer V, Matoulek M, Parízková J, Zák A, Svacina S. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol Res. 2006;55(1):63-72. Epub 2005 Apr 26
  • Tai CC, Ding ST. N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention. J Nutr Biochem. 2010 May;21(5):357-63. Epub 2010 Feb 9. Review.

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