Study sees overlapping anti-arthritis benefits from fish plus broccoli or other sulfurous greens 08/04/2014
What is osteoarthritis?
Osteoarthritis or OA is the “regular” kind of arthritis that comes with age, and affects people in varying ways.
OA can be mild or severe, and may affect different joints at different ages, depending on a person's occupation, lifestyle, and genetics.
The condition is characterized by breakage or loss of cartilage … the hard, slippery connective tissue that covers the ends of bones where they meet to form a joint.
According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, OA afflicts 27 million Americans over the age of 25, with most patients being over age 50.
Younger people can develop OA, usually as the result of a joint injury, malformation, or genetic defect, but it OA becomes more common with age.
Before age 45, more men than women have osteoarthritis; after age 45, it is more common in women.
It's also more likely to occur in people who are overweight and in those with jobs that stress particular joints.
About one in five people over the age of 45 has osteoarthritis in their knee.
There is no cure or effective treatment other than pain relief, which is often inadequate (or causes adverse gastric effects), or joint replacement.
Exercise and weight control can improve OA symptoms and reduce the chances of the disease progressing.
But no research has yet proven that diet can contribute to prevention or treatment … although greens and garlic are linked to lower risk (Williams FM et al. 2010).
- Rich in saturated fat
- Rich in omega-6 fatty acids
- Rich in omega-6 fatty acids, with a small dose of omega-3 fatty acids
Control diet (normal mouse chow)
Test diet: mouse chow enriched with sulforaphane
- Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage. 2012 May;20(5):382-7. doi: 10.1016/j.joca.2012.01.021. Epub 2012 Feb 4
- Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage. 2014 Jul 4. pii: S1063-4584(14)01156-X. doi: 10.1016/j.joca.2014.06.033. [Epub ahead of print]
- Davidson RK, Jupp O, de Ferrars R, Kay CD, Culley KL, Norton R, Driscoll C, Vincent TL, Donell ST, Bao Y, Clark IM. Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis Rheum. 2013 Dec;65(12):3130-40. doi: 10.1002/art.38133.
- Duke University Health System (DUHS). Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice. July 11, 2014. Accessed at http://corporate.dukemedicine.org/news_and_publications/news_office /news/ omega-3-fatty-acids-lessen-severity-of-osteoarthritis-in-mice
- Green JA, Hirst-Jones KL, Davidson RK, Jupp O, Bao Y, MacGregor AJ, Donell ST, Cassidy A, Clark IM. The potential for dietary factors to prevent or treat osteoarthritis. Proc Nutr Soc. 2014 May;73(2):278-88. doi: 10.1017/S0029665113003935. Epub 2014 Feb 26.
- Knott L, Avery NC, Hollander AP, Tarlton JF. Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease. Osteoarthritis Cartilage. 2011 Sep;19(9):1150-7. doi: 10.1016/j.joca.2011.06.005. Epub 2011 Jul 1.
- Rosenbaum CC, O'Mathúna DP, Chavez M, Shields K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern Ther Health Med. 2010 Mar-Apr;16(2):32-40. Review.
- University of East Anglia (UEA). Broccoli could be key in the fight against osteoarthritis. August 28, 2013. Accessed at http://www.uea.ac.uk/mac/comm/media/press/2013/ August/broccoli-osteoarthritis-research-sulforaphane
- Wang Y, Wluka AE, Hodge AM, English DR, Giles GG, O'Sullivan R, Cicuttini FM. Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis. Osteoarthritis Cartilage. 2008 May;16(5):579-83. Epub 2007 Oct 15.
- Williams FM, Skinner J, Spector TD, Cassidy A, Clark IM, Davidson RM, MacGregor AJ. Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskelet Disord. 2010 Dec 8;11:280. doi: 10.1186/1471-2474-11-280.
- Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F. Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. Ann Rheum Dis. 2014 Jul 10. pii: annrheumdis-2014-205601. doi: 10.1136/annrheumdis-2014-205601. [Epub ahead of print]