Post-Traumatic Stress Disorder (PTSD) is commonly associated with soldiers.
Combat is the most common cause of PTSD in men today, simply because of the large number who've been in or around combat since 9/11. Female soldiers are at risk too, but there are fewer of them.
Most PTSD cases occur in response to domestic violence (physical or psychological), rape, assault (actual or threatened), serious car accidents, and natural or manmade disasters.
But not everyone who undergoes a fearful experience gets PTSD, and genetics or life history can raise a person's risk for PTSD.
Animal studies suggest that the risk of PTSD rises when blood levels of stress hormones are chronically elevated, due to chronic exposure to stress … such as in combat zones and abusive households.
Four symptoms define PTSD:
- Re-experiencing the trauma routinely
- Chronic muscle and emotional tension
- Avoiding situations that may be reminders of the event
- Persistent negative thinking and mood or emotional numbing
People with PTSD feel stressed, anxious, depressed, or frightened even when they're no longer in danger.
As yet, there are no proven drug or natural therapies for PTSD.
Prior research shows that curcumin is very good for brain health ... and a new animal study suggests that it may help prevent PTSD.
We'll review that evidence before summarizing the results of the new study in rats.
Earlier studies on curcumin and brain-mood health
The results of prior research into curcumin's effects on brain and nervous system health have been almost uniformly positive.
Five years ago, and again earlier this year, Chinese researchers reported that curcumin largely prevented depression caused by “chronic, unpredictable, mild, stress” or CUMD (Li YC et al. 2009; Zhang L et al. 2014).
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Interestingly, animal studies indicate that other plant compounds hold promise: resveratrol from grapes, garcinol from Kokum tree fruit, piperine from black pepper, and glycosides from peony root (Liu D et al. 2014; Maddox SA et al. 2013; Mao QQ et al. 2014; Mao QQ et al. 2009).
Now, an animal study indicates that curcumin – the antioxidant pigment that makes turmeric root orange – may help prevent PTSD and amelioriate its symptoms.
Of course, it's important to stress that the benefits of a drug or food factor (like curcumin) in animals may not apply to people.
Curcumin hindered consolidation and recall of fearful memories in rats
The new animal study was led by Glenne Schafe, Ph.D., professor of psychology at New York City's Hunter College (Monsey MS et al. 2014).
His lab studies the roots of emotional learning and memory, including the kinds of fear conditioning that drive the development of PTSD.
Dr. Schafe's team studies how new fear memories transform into stable, long-term memories, and how retrieval of an old fear memory may be strengthened or weakened, and how exposure to chronic stress alters the consolidation fear memories.
In their new study, the Hunter College researchers found that curcumin impaired the formation of fear memories in rat's brains following a traumatic experience.
As Schafe put it, “We showed that rats fed a diet enriched with curcumin have impaired encoding of fear memories. We also showed that rats with a pre-existing fear memory can lose that memory when it is recalled while they are eating a curcumin-enriched diet.” (HC 2014)
The New York team found that fear memories impaired by curcumin remained weak for a long period, thereby preventing them from “reconsolidating”.
The authors concluded that their findings may have “important clinical implications for the treatment of disorders such as PTSD that are characterized by unusually strong and persistently reactivated fear memories.” (Monsey MS et al. 2014)
We certainly hope so.
Sadly, U.S. patent laws and lack of public funding for clinical trials make it very difficult to gain FDA approval for curcumin as a therapy for anything … despite its obvious promise for multiple health conditions.
- Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem. 2003 Dec;52(4):177-81. Review.
- Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504. doi: 10.4103/0974-8520.110524.
- Hunter College (HC). Hunter Professor Glenn E. Schafe Discovers New Medicinal Properties of Popular Indian Spice. December 2014. Accessed at http://www.hunter.cuny.edu/communications/pressroom/news/hunter-professor-glenn-e.-schafe-discovers-new-medicinal-properties-of-popular-indian-spice
- Li YC, Wang FM, Pan Y, Qiang LQ, Cheng G, Zhang WY, Kong LD. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):435-49. doi: 10.1016/j.pnpbp.2009.01.006. Epub 2009 Jan 22.
- Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-
- Liu D, Xie K, Yang X, Gu J, Ge L, Wang X, Wang Z. Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behav Brain Res. 2014 May 1;264:9-16. doi: 10.1016/j.bbr.2014.01.039. Epub 2014 Feb 4.
- Maddox SA, Watts CS, Doyère V, Schafe GE. A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories. PLoS One. 2013;8(1):e54463. doi: 10.1371/journal.pone.0054463. Epub 2013 Jan 21.
- Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP. Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats. Cell Mol Neurobiol. 2014 Apr;34(3):403-8. doi: 10.1007/s10571-014-0025-1. Epub 2014 Jan 9.
- Mao QQ, Ip SP, Ko KM, Tsai SH, Che CT. Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1211-6. doi: 10.1016/j.pnpbp.2009.07.002. Epub 2009 Jul 21. Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neurol. 2008 Jan;11(1):13-9. doi: 10.4103/0972-2327.40220.
- Monsey MS, Boyle LM, Zhang ML, Nguyen CP, Kronman HG, Ota KT, Duman RS, Taylor JR, Schafe GE. Chronic corticosterone exposure persistently elevates the expression of memory-related genes in the lateral amygdala and enhances the consolidation of a Pavlovian fear memory. PLoS One. 2014 Mar 11;9(3):e91530. doi: 10.1371/journal.pone.0091530. eCollection 2014.
- Monsey MS, Gerhard DM, Boyle LM, Briones MA, Seligsohn M, Schafe GE. A Diet Enriched With Curcumin Impairs Newly Acquired and Reactivated Fear Memories. Neuropsychopharmacology. 2014 Nov 28. doi: 10.1038/npp.2014.315. [Epub ahead of print]
- Monsey, M.S., Ota, K.T., Akingbade, I.F., Hong, E.S. & Schafe, G.E. (2011). Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS ONE, 6(5): e19958. doi:10.1371/journal.pone.0019958.
- Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.
- Zhang L, Luo J, Zhang M, Yao W, Ma X, Yu SY. Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats. Int J Neuropsychopharmacol. 2014 May;17(5):793-806. doi: 10.1017/S1461145713001661. Epub 2014 Jan 9.