Turmeric root gives curry powders their characteristic yellow-orange hue.
And turmeric has long been prized in Chinese and Indian medicine as a broadly beneficial “tonic” herb.
Modern scientific research focuses on turmeric's trio of yellow-orange pigments, collectively called “curcumin”.
Lab experiments and preliminary clinical studies indicate that this synergistic trio of polyphenol compounds supports immune and brain health in powerful ways.
Curcumin exerts so-called “nutrigenomic” effects on our genes … ones that moderate inflammation and stimulate the body's own antioxidant defenses (see “Curcumin Trial Reveals Broad Benefits
Curcumin buyers beware
Sadly, curcumin is not well-absorbed when extracted from turmeric ... unless something is done to change that.
Some manufacturers add piperine from black pepper, while others package curcumin in fatty envelopes called liposomes (a very costly approach).
But the simplest, most cost-effective, and beneficial method is to include turmeric's own volatile oils along with the curcumin.
Research shows that turmeric's volatile oils enhance the benefits of curcumin and provide their own.
Accordingly, when we decided to offer a Curcumin in Wild Salmon Oil
supplement, we picked a patented extract called BCM-95®, which includes the full spectrum of turmeric volatile oils.
Clinical studies show that BCM-95 curcumin is absorbed six to seven times better than the curcumin in conventional 95%-curcumin dietary supplements (Antony B et al. 2012).
Last year, U.S. and Indian scientists published a clinical trial that added more evidence of curcumin's potential as a brain-health ally … see “Curry's Color Boosts Mood
Two recent clinical trials examined the effect of curcumin on mood, concentration, memory, and fatigue … and they detected significant benefits in all four areas.
Iranian trial finds curcumin boosted antidepressant benefits
And, judging by the results of a preliminary trial, it appears that curcumin may offer similar benefits.
Last August, Iranian doctors published the results of a clinical trial in which they tested the effects of supplemental curcumin in patients suffering from major depression (Panahi Y et al. 2014).
As the authors wrote, “Current medications have limited efficacy in controlling the symptoms of major depressive disorder (MDD), and are associated with several adverse events on long-term use.”
They explained why they chose to test adding curcumin to therapy with antidepressant drugs:
“Curcuminoids are extremely safe and … have been shown to alleviate depressive symptoms in a variety of experimental models.”
The Iranian team recruited 111 depression patients and assigned them to one of two groups for a six-week trial:
The curcumin supplement contained piperine: a black pepper compound proven to improve the absorption of curcumin … see our sidebar, “Curcumin buyers beware”.
Before and after the trial, the mood health of all participants was measured using two standard tests.
At the end of the trial, the mood scores improved in both groups.
However, the mood-score improvements were significantly greater in the curcumin group.
As they concluded, “Co-administration of curcuminoids with piperine may be used as a safe and effective add-on to standard antidepressants in patients with MDD [major depressive disorder].” (Panahi Y et al. 2014)
Australian study sees curcumin improving seniors' concentration and energy
The second clinical trial comes from the Centre for Human Psychopharmacology at Australia's Swinburne University of Technology (Cox KH et al. 2014).
It was led by Professor Andrew Scholey, whose team has tested other herbs believed to boost mental performance – sage, American ginseng, Panax (Chinese) ginseng, and lemon balm – with measureable successes.
Based on the success of earlier curcumin studies, they were keen to test its effect on mental acuity.
As his co-author — PhD student Katherine Cox — said, “Curcumin has sparked widespread interest, with epidemiological studies suggesting that cultures with a diet rich in curries have better cognitive function and a lower prevalence of dementia.” (SUT 2014)
She cited evidence that the curcumin in turmeric may account for the relatively low dementia rates seen in curry-loving South Asian countries.
For example, researchers from Singapore found that people who consumed curry dishes routinely performed significantly better on mental tests, compared with those who never or rarely ate curries (Ng TP et al. 2006).
Dr. Scholey's team was aware that standard supplemental curcumin is not well-absorbed:
“One issue found in preclinical animal studies, was that pure curcumin given orally is not well absorbed, making it less powerful,” said Ms. Cox (SUT 2014).
The randomized, double-blind, placebo-controlled trial examined the effects of curcumin on cognitive function and mood in 60 healthy adults aged 60 to 85.
Scholey's team measured the effects of curcumin in three different contexts:
The results were very encouraging: participants showed significant improvements in attention one hour after taking curcumin, and this benefit persisted after four weeks of daily consumption.
And the participants reported an additional benefit after four weeks of daily curcumin … less fatigue.
As Cox said, “What really surprised us was that the chronic effect of curcumin was associated with significantly lower levels of fatigue, compared with the placebo group.” (SUT 2014)
“Fatigue in the elderly is quite important for health and psychological reasons and interventions such as curcumin … may have the potential to reduce vulnerability to depression and anxiety disorders,” she added (SUT 2014).
This was the second trial to detect anti-fatigue effects from curcumin.
Five years ago, Indian researchers found that patients who took curcumin supplements after gall bladder surgery reported reduced pain and postoperative fatigue, compared with those who took placebo pills (Agarwal KA et al. 2011).
The Swinburne University study was supported by funding from Verdure Sciences™ Pty, maker of the curcumin supplement used in the trial.
Agarwal KA, Tripathi CD, Agarwal BB, Saluja S. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surg Endosc. 2011 Dec;25(12):3805-10. doi: 10.1007/s00464-011-1793-z. Epub 2011 Jun 14.
Apetz N, Munch G, Govindaraghavan S, Gyengesi E. Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease - a translational perspective. CNS Neurol Disord Drug Targets. 2014;13(7):1175-91.
Banji OJ, Banji D, Ch K. Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain. Food Chem Toxicol. 2014 Sep 16;74C:51-59. doi: 10.1016/j.fct.2014.08.020. [Epub ahead of print]
Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct 2. pii: 0269881114552744. [Epub ahead of print]
Hoppe JB, Coradini K, Frozza RL, Oliveira CM, Meneghetti AB, Bernardi A, Pires ES, Beck RC, Salbego CG. Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3β signaling pathway. Neurobiol Learn Mem. 2013 Nov;106:134-44. doi: 10.1016/j.nlm.2013.08.001. Epub 2013 Aug 14.
Kaur H, Bal A, Sandhir R. Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. Pharmacol Biochem Behav. 2014 Oct;125:55-64. doi: 10.1016/j.pbb.2014.08.001. Epub 2014 Aug 10.
Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006 Nov 1;164(9):898-906. Epub 2006 Jul 26.
Panahi Y, Badeli R, Karami GR, Sahebkar A. Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder. Phytother Res. 2014 Aug 4. doi: 10.1002/ptr.5211. [Epub ahead of print]
Swinburne University of Technology (SUT). Curcumin: A spice extract that improves fatigue. October 27, 2014. http://www.swinburne.edu.au/media-centre/news/2014/10/curcumin-a-spice-extract-that-improves-fatigue.html
Tian M, Zhang X, Wang L, Li Y. Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats. Am J Chin Med. 2013;41(5):1027-42. doi: 10.1142/S0192415X13500699.
Tiwari SK, Agarwal S, Seth B, Yadav A, Nair S, Bhatnagar P, Karmakar M, Kumari M, Chauhan LK, Patel DK, Srivastava V, Singh D, Gupta SK, Tripathi A, Chaturvedi RK, Gupta KC. Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway. ACS Nano. 2014 Jan 28;8(1):76-103. doi: 10.1021/nn405077y. Epub 2013 Dec 10.
Wu A, Ying Z, Gomez-Pinilla F. Dietary strategy [curcumin] to repair plasma membrane after brain trauma: implications for plasticity and cognition. Neurorehabil Neural Repair. 2014 Jan;28(1):75-84. doi: 10.1177/1545968313498650. Epub 2013 Aug 1.
Yu SY, Zhang M, Luo J, Zhang L, Shao Y, Li G. Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:47-53. doi: 10.1016/j.pnpbp.2013.05.001. Epub 2013 May 8.